Photodynamic therapy (PDT) is a well-established clinical modality for cancer, dermatological, and dental diseases. PDT is based on the activation of photosensitizer agents with a specific wavelength of light, which results in energy transfer cascades that ultimately yield cytotoxic reactive oxygen species that can render cell death. The Fundamentals of photodynamic therapy (type I or II mechanisms, its cellular and biochemical aspects will be extensively described. The photosensitizers, in particular, those used clinically will be presented. The different light sources for inducing the photochemical reaction will be detailed. Specific examples such as “PDT for prostate cancer treatment» and « PDT for actinic keratosis treatment » will be presented.
Antimicrobial photodynamic therapy (aPDT) or photodynamic inactivation (PDI) is a new promising strategy to eradicate pathogenic microorganisms such as Gram-positive and Gram-negative bacteria, yeasts and fungi. Pathogens’ susceptibility to aPDT will be studied. Photosensitizers and light source used for a PDT will be described. Specific examples such as “Antimicrobial photodynamic therapy in Dentistry “ will be discussed.
Prof. Serge R. Mordon, PhD works in Lille, France for the French National Institute of Health and Medical Research (INSERM). He is the director of INSERM U 1189 (Image Assisted Laser Therapies Assisted for Oncology) and the director of the Photomedicine Center (Lille University Hospital). Since 1981, he has been involved in the medical applications of lasers, particularly in dermatology and plastic surgery. More recently, he has focused his research on Focal Laser Ablation and Photodynamic Therapy.
He is an internationally recognized expert in laser-tissue interaction and laser applications in medicine. He has authored over 400 articles and book chapters. Pr. Mordon is the author of sixteen issued patents. Since 2012, he holds a Master Degree in Strategy and Organization Management (University of Paris X).
He is the President of The French Medical Laser Society and Board Member of several professional societies. Associate editor of the editorial board for the journal Lasers in Surgery and Medicine. In 2015, he was nominated Finland Distinguished Professor.